You should take periodic breaks from taking quercetin. Pregnant women, breastfeeding women, and people with kidney disease should avoid quercetin. At doses greater than 1 g per day, there have been reports of damage to the kidneys.
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Is quercetin safe for everyone?
When taken by mouth: Quercetin is possibly safe for most people when used short-term Quercetin has been safely used in doses up to 1 gram daily for 12 weeks. It’s not known if long-term use or higher doses are safe.
Does quercetin affect blood pressure?
Quercetin seems to decrease blood pressure Taking quercetin along with medications for high blood pressure might cause your blood pressure to go too low.
Can quercetin be toxic?
However, studies have also shown that quercetin has potentially toxic effects , including its mutagenicity, prooxidant activity, mitochondrial toxicity, and inhibition of key enzymes involved in hormone metabolism [9], [10].
Does quercetin affect the heart?
Quercetin exhibits significant heart related benefits as inhibition of LDL oxidation, endothelium-independent vasodilator effects, reduction of adhesion molecules and other inflammatory markers, the protective effect on nitric oxide and endothelial function under conditions of oxidative stress, prevention of neuronal..
Does quercetin interact with any medications?
Interactions. Be careful if you are taking drugs such as antibiotics, cyclosporine, warfarin, or drugs that are changed by the liver. Quercetin may change how these drugs work and raise the risk of side effects. There don’t appear to be interactions between quercetin and foods or other herbs and supplements.
What are the side effects of quercetin?
Common side effects of quercetin include: Headache (oral use) Numbness and tingling (oral use) Shortness of breath (intravenous use) Nausea and vomiting (intravenous use) Kidney damage (intravenous use greater than 945 mg/m2).
Should quercetin be taken on an empty stomach?
Quercetin can have mild side effects like an upset stomach or headache, particularly if you take it on an empty stomach If you take prescription medication, consult with your doctor before adding quercetin to your regimen, as drug interactions can cause additional side effects.
Does quercetin affect sleep?
In contrast, the increase in non-REM sleep induced by quercetin was not affected by i.c.v. injection of bicuculline. Therefore, the present results suggest that quercetin alters the sleep-wake cycle partly through activation of GABA(A) receptors.
Can you take NAC with high blood pressure?
It further suggests that supplementary agents such as NAC, which increase endogenous levels of these thiols, or intake of dietary NAC or cysteine-containing proteins, may be useful in controlling high blood pressure.
Is CoQ10 the same as quercetin?
Just like quercetin, CoQ 10 showed antioxidant effects in our study on human nasal mucosal cells OTMs were reduced significantly by both concentrations used after cells were stressed by oxidants. No significant difference was found between the two concentrations (1 μM and 10 μM).
Does quercetin boost immune system?
Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system , antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production.
Are CoQ10 and quercetin the same thing?
Antioxidants, such as coenzyme Q10 (CoQ10) and quercetin, a member of flavonoids present in red wine and tea , are thought to play a significant role in protecting cells from oxidative stress induced by reactive oxygen species (ROS).
Does quercetin cause anxiety?
Aside from antioxidant properties, quercetin also has an anti-inflammatory activity on some animal models [14], [15]. Moreover, several studies have reported that quercetin affects some behavioral responses, such as depressive-like and anxiety-like behaviors induced by physical stress [15], [16], [17].
Does quercetin raise your heart rate?
Blood pressure and heart rate Heart rate was also significantly reduced by quercetin in SHR (−12%) (Figure 1B). Effects of quercetin on arterial blood pressure and heart rate.
Does quercetin cause chest pain?
Signs of a very bad reaction. These include wheezing; chest tightness ; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Go to the ER right away.
What food has the most quercetin?
Quercetin is contained in abundance in apples, honey, raspberries, onions, red grapes, cherries, citrus fruits, and green leafy vegetables [2]. Among vegetables and fruits, quercetin content is highest in onions. The bulb color and type seems to be a determining factor for quercetin concentration in onions.
Can you take NAC and quercetin together?
This is why quercetin should always be co-administered with vitamin C and NAC When taken together, these nutrients have a synergistic effect beyond what any of them can provide individually.
Is quercetin an antiviral?
Quercetin displays a broad range of antiviral properties which can interfere at multiple steps of pathogen virulence -virus entry, virus replication, protein assembly- and that these therapeutic effects can be augmented by the co-administration of vitamin C.
How quickly does quercetin lower blood pressure?
Duration of supplementation with quercetin ranged between 4 and 10 weeks Five trials were designed as parallel‐group studies and 2 trials as 2×2 crossover design. Among all studies included in this meta‐analysis, only 1 study included men and women with prehypertension and stage 1 hypertension.
Does quercetin cause weight gain?
Quercetin was supposed to be an activator of oxidative metabolism [9] and it also may inhibit adipogenesis [1]. But taken together, our data show that quercetin is not able to decrease either weight gain or feed efficiency as hypothesized, because no differences were found between placebo and the quercetin group.
Can you have too much glutathione?
Taking glutathione long-term has been linked to lower zinc levels Inhaled glutathione may trigger asthma attacks in people who have asthma. Symptoms may include wheezing. Risks.
What are the benefits of quercetin supplements?
Possible health benefits of quercetin include: Fighting free radicals. Quercetin has antioxidant properties… Reducing inflammation… Reducing the risk of cancer… Preventing neurological diseases… Relieving allergy symptoms… Preventing infections… Reducing the risk of heart disease… Lowering high blood pressure.
How long does quercetin stay in your system?
Human subjects can absorb significant amounts of quercetin from food or supplements, and elimination is quite slow, with a reported half-life ranging from 11 to 28 h [38]. The average terminal half-life of quercetin is 3.5 h [39].
Is quercetin good for AFIB?
Quercetin may alleviate AF by inhibiting fibrosis of atrial tissues through inhibiting TGF-β/Smads pathway via promoting miR-135b expression.
Does quercetin lower cholesterol?
Test tube studies show that quercetin prevents damage to LDL cholesterol , and population studies show that people who eat diets high in flavonoids have lower cholesterol. One study found that people who took quercetin and an alcohol-free red wine extract (which contains quercetin) had less damage to LDL cholesterol.