Phenylalanine can cause intellectual disabilities, brain damage, seizures and other problems in people with PKU Phenylalanine occurs naturally in many protein-rich foods, such as milk, eggs and meat. Phenylalanine is also sold as a dietary supplement.
What are the side effects of phenylalanine?
Side effects may include: Heartburn. Fatigue. Nausea. Constipation. Dizziness. Headache. Anxiety and hypomania (a milder form of mania) Sedation.
Is phenylalanine safe to eat?
For healthy adults, phenylalanine is considered safe in the quantities found naturally in foods However, individuals with phenylketonuria (PKU) cannot metabolize it and must minimize their intake to prevent adverse health effects.
What happens when phenylalanine accumulates in the body?
Phenylalanine is an essential nutrient, but some individuals are born with a genetic disorder, phenylketonuria (PKU), that prevents them from metabolizing phenylalanine, and, if untreated, phenylalanine accumulates in the body, becomes converted into phenylpyruvate , and the individual usually develops seizures, brain..
How much phenylalanine is safe?
When taken by mouth: L-phenylalanine is LIKELY SAFE for most people when taken in amounts commonly found in foods. L-phenylalanine is POSSIBLY SAFE when taken as medicine, short-term. D-phenylalanine is POSSIBLY SAFE when used as a single dose of up to 10 grams.
What are the benefits of DLPA?
DLPA (or the D- or L- form alone) reduced depression in 31 of 40 people in a preliminary trial. Some doctors suggest a one-month trial with 3–4 grams per day of phenylalanine for people with depression, although some researchers have found that even very low amounts—75–200 mg per day—were helpful in preliminary trials.
Does phenylalanine help with weight loss?
The researchers found that the single-dose of phenylalanine reduced food intake, increased levels of GLP-1 and decreased levels of ghrelin Repeated administration also caused weight loss in the obese mice. The researchers also observed that the rats were moving around more, which might encourage them to lose weight.
Do humans need phenylalanine normally?
Phenylalanine is an essential nutrient , but some individuals are born with a genetic disorder, phenylketonuria (PKU), that prevents them from metabolizing phenylalanine, and, if untreated, phenylalanine accumulates in the body, becomes converted into phenylpyruvate, and the individual usually develops seizures, brain..
Does phenylalanine increase dopamine?
L-Phenylalanine can boost levels of the neurotransmitters dopamine , norepinephrine and epinephrine. And can help a sluggish thyroid produce more T4 and T3. L-Phenylalanine can help boost cognition especially in stressful situations.
Does phenylalanine raise blood sugar?
Conclusion: In summary, phenylalanine in an amount moderately greater than that in a large protein meal stimulates an increase in insulin and glucagon concentration. It markedly attenuates the glucose-induced rise in plasma glucose when ingested with glucose.
How is phenylalanine toxic to the brain?
The high plasma phenylalanine concentrations increase phenylalanine entry into brain and restrict the entry of other large neutral amino acids In the literature, emphasis has been on high brain phenylalanine as the pathological substrate that causes mental retardation.
When should I take L phenylalanine?
For best results, phenylalanine should be taken between meals , because the protein present in food can interfere with the uptake of phenylalanine into the brain, potentially reducing its effect.
Why is phenylalanine in Coke?
Along with other substances, Phenylalanine contributes to the formation of an important neurotransmitter (a brain chemical which transmits nerve impulses). This neurotransmitter enhances mental alertness and memory and improves mood.
What foods are high in phenylalanine?
Phenylalanine is found in most protein-containing foods such as milk, eggs, cheese, nuts, soybeans, chicken, beef, pork, beans and fish.
Is phenylalanine a vegetable?
The percentage of Phe in protein varied from 3.13 ± 1.03% to 3.74 ± 2.55% in fruits; 3.33 ± 1.41 to 4.82 ± 1.17 in type-A vegetables; 3.46 ± 1.25% to 4.83 ± 2.46 in type-B vegetables; and 3.14% ± 1.49 to 4.62% ± 2.26 in type-C vegetables.
Is phenylalanine an antidepressant?
It is concluded that dl-phenylalanine might have substantial antidepressant properties and that further controlled investigations are justified.
Is phenylalanine a drug?
Phenylalanine is used for depression, attention deficit-hyperactivity disorder (ADHD), Parkinson’s disease, chronic pain, osteoarthritis, rheumatoid arthritis, alcohol withdrawal symptoms, and a skin disease called vitiligo Some people apply it directly to the skin for vitiligo.
Can phenylalanine cause insomnia?
Aspartame (α-aspartyl-l-phenylalanine-o-methyl ester), an artificial sweetener, has been linked to behavioral and cognitive problems. Possible neurophysiological symptoms include learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia.
Is phenylalanine the same as aspartame?
Phenylalanine is one of two amino acids that make up aspartame Aspartame provides significantly lower amounts of phenylalanine than everyday food sources, such as meat, fish, eggs, and dairy products. People with PKU need to monitor all dietary sources of phenylalanine to avoid toxic levels.
Is phenylalanine a caffeine?
Phenylalanine is an amino acid that gets depleted from the use of caffeine.